220099-91-2
220099-91-2
Chemical Structure
AZD0328
- CAS No.: 220099-91-2
- Formula:C13H16N2O
- Molecular Weight:216.28
IUPAC Name: (2R)-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine]
InChIKey: OCKIPDMKGPYYJS-ZDUSSCGKSA-N
SMILES: N12CC[C@@H](CC2)[C@@]3(OC4=NC=CC=C4C3)C1
Biological Activity: AZD0328 is a selective α7 nAChR partial agonist. AZD0328 selectively enhances midbrain dopaminergic neuronal activity and enhances cortical dopamine levels in rats. AZD0328 improves cognitive performance[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
AZD0328 | AZD0328 is a selective α7 nAChR partial agonist. AZD0328 selectively enhances midbrain dopaminergic neuronal activity and enhances cortical dopamine levels in rats. AZD0328 improves cognitive performance. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Sydserff S, et al. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. [Content Brief]
- [2]. Castner SA, et al. Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors. Biol Psychiatry. 2011 Jan 1;69(1):12-8. [Content Brief]
Keywords
