220614-50-6
220614-50-6
Chemical Structure
ABT-770
- CAS No.: 220614-50-6
- Formula:C22H22F3N3O6
- Molecular Weight:481.42
IUPAC Name: (S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-3-((4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)oxy)propan-2-yl)-N-hydroxyformamide
InChIKey: IIHFBHZWJNGWRC-INIZCTEOSA-N
SMILES: O=CN([C@@H](CN(C(NC1(C)C)=O)C1=O)COC2=CC=C(C3=CC=C(OC(F)(F)F)C=C3)C=C2)O
Biological Activity: ABT-770 (compound 11) is a highly selective and orally active MMP inhibitor, demonstrating over 1000-fold selectivity for MMP-2 (IC50=4 nM) compared to MMP-1 (IC50=4600 nM). ABT-770 can be utilized in studies related to tumor growth, invasion, and metastasis[1].
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ABT-770 | ABT-770 (compound 11) is a highly selective and orally active MMP inhibitor, demonstrating over 1000-fold selectivity for MMP-2 (IC50=4 nM) compared to MMP-1 (IC50=4600 nM). ABT-770 can be utilized in studies related to tumor growth, invasion, and metastasis. | |||||||||||||||||||||
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