220643-77-6
220643-77-6
Chemical Structure
p-MPPI hydrochloride
- CAS No.: 220643-77-6
- Formula:C25H28ClIN4O2
- Molecular Weight:578.87
IUPAC Name: 4-iodo-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)benzamide hydrochloride
InChIKey: PBPBIDMIRMWUCI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)I)N(C2=NC=CC=C2)CCN3CCN(CC3)C4=CC=CC=C4OC.[H]Cl
Biological Activity: p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
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p-MPPI hydrochloride | 99.70% | p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects. | ||||||||||||||||||||
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References
- [1]. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7. [Content Brief]
- [2]. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71. [Content Brief]
Keywords
