1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. p-MPPI hydrochloride

p-MPPI hydrochloride 

Cat. No.: HY-120738 Purity: 99.19%
Handling Instructions

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.

For research use only. We do not sell to patients.

p-MPPI hydrochloride Chemical Structure

p-MPPI hydrochloride Chemical Structure

CAS No. : 220643-77-6

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10 mM * 1  mL in DMSO USD 110 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].

IC50 & Target[1]

5-HT1A Receptor

 

In Vitro

p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1].

In Vivo

p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2].

Animal Model: Adult male Swiss Webster mice (aged 8-9 weeks)[2]
Dosage: 0.5, 1.5, 4.5 mg/kg
Administration: i.p.
Result: Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.
Molecular Weight

578.87

Formula

C₂₅H₂₈ClIN₄O₂

CAS No.

220643-77-6

SMILES

O=C(C1=CC=C(C=C1)I)N(C2=NC=CC=C2)CCN3CCN(CC3)C4=CC=CC=C4OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 17.86 mg/mL (30.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7275 mL 8.6375 mL 17.2750 mL
5 mM 0.3455 mL 1.7275 mL 3.4550 mL
10 mM 0.1728 mL 0.8638 mL 1.7275 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.79 mg/mL (3.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.79 mg/mL (3.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.79 mg/mL (3.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

p-MPPI5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorligandanxietydisordersantidepressant-likeaffinityselectivesleepInhibitorinhibitorinhibit

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Product Name:
p-MPPI hydrochloride
Cat. No.:
HY-120738
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