2222129-13-5
2222129-13-5
Chemical Structure
PDD-87
- CAS No.: 2222129-13-5
- Formula:C20H21ClN6O2S
- Molecular Weight:444.94
InChIKey: HCABCQKOHPXKHW-ZDUSSCGKSA-N
SMILES: ClC1=CC=CC(C)=C1NC(C2=CN=C(NC3=NC(C)=NC(N4CC[C@H](O)C4)=C3)S2)=O
Biological Activity: PDD-87 is an orally active, blood-brain barrier permeable kinase inhibitor, with IC50 values ranging from 0.07 nM to 0.72 nM against ABL, SRC family, BTK kinases and their key mutants. PDD-87 induces antiproliferative effects in leukemia and lymphoma cells, and inhibits tumor growth in mouse xenograft models. PDD-87 can be used for the research of leukemia and lymphoma[1].
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PDD-87 | PDD-87 is an orally active, blood-brain barrier permeable kinase inhibitor, with IC50 values ranging from 0.07 nM to 0.72 nM against ABL, SRC family, BTK kinases and their key mutants. PDD-87 induces antiproliferative effects in leukemia and lymphoma cells, and inhibits tumor growth in mouse xenograft models. PDD-87 can be used for the research of leukemia and lymphoma. | |||||||||||||||||||||
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References
Keywords
