2222354-91-6

SNIPER(ER)-87 Chemical Structure
2222354-91-6

Chemical Structure

SNIPER(ER)-87

  • CAS No.: 2222354-91-6
  • Formula:C59H73N5O10S
  • Molecular Weight:1044.30

IUPAC Name: (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(3-((1-(4-((E)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenoxy)-3-methyl-4-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)oxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide

InChIKey: ILLYWIKUEZHTSD-MEWFHHHASA-N

SMILES: C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCC(N(C)CCOC5=CC=C(/C(C6=CC=C(O)C=C6)=C(C7=CC=CC=C7)\CC)C=C5)=O)=C4)=O)=CS3)CCC2)=O)=O

Biological Activity: SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2].

Cat. No. Product Name Purity Description Pricing
HY-129619 		SNIPER(ER)-87 99.2% SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation.
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