2222660-40-2
Chemical Structure
DNDI-8219
- CAS No.: 2222660-40-2
- Formula:C13H10F3N3O5
- Molecular Weight:345.23
IUPAC Name: (R)-2-nitro-6-(4-(trifluoromethoxy)phenoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
InChIKey: IXUWKDINJWESQG-SNVBAGLBSA-N
SMILES: FC(F)(F)OC1=CC=C(O[C@@H]2CN3C(OC2)=NC([N+]([O-])=O)=C3)C=C1
Biological Activity: DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
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DNDI-8219 | DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety. | |||||||||||||||||||||
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