2226257-92-5
2226257-92-5
Chemical Structure
NS-062
- CAS No.: 2226257-92-5
- Formula:C28H30Cl2F2N6O4
- Molecular Weight:623.48
IUPAC Name: (2R)-1-(2-chloro-2-fluoroacetyl)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide
InChIKey: CNRKPZFTXUAKCP-XQZUBTRRSA-N
SMILES: FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OCCCN4CCOCC4)=C(NC([C@H]5CCCN5C(C(Cl)F)=O)=O)C=C32
Biological Activity: NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy in drug-resistant double mutated H1975 cell with an IC50 of 0.19 μM. NS-062 exhibits antitumor efficacy in mouse H1975 xenograft model[1].
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NS-062 | NS-062 is an orally active, irreversible targeted covalent inhibitor for EGFR, and exhibits antiproliferative efficacy in drug-resistant double mutated H1975 cell with an IC50 of 0.19 μM. NS-062 exhibits antitumor efficacy in mouse H1975 xenograft model. | |||||||||||||||||||||
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