2230873-75-1
Chemical Structure
KRAS inhibitor-15
- CAS No.: 2230873-75-1
- Formula:C20H17Cl2FN4OS
- Molecular Weight:451.34
IUPAC Name: 1-(4-(6-(5-amino-2-chlorophenyl)-5-chloro-7-fluorobenzo[c]isothiazol-3-yl)piperazin-1-yl)prop-2-en-1-one
InChIKey: RIJPTYRYUVYJJH-UHFFFAOYSA-N
SMILES: C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(N)=CC=C4Cl)=C(C3=NS2)F)Cl)=O
Biological Activity: KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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KRAS inhibitor-15 | KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
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Keywords
