2241547-82-8
Chemical Structure
hGGPPS-IN-2
- CAS No.: 2241547-82-8
- Formula:C20H18FN5O7P2S
- Molecular Weight:553.40
IUPAC Name: (((2-(3-(3-(4-fluorophenyl)ureido)phenyl)thieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
InChIKey: ADZFVWRKYSFEGP-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C2=NC(NC(P(O)(O)=O)P(O)(O)=O)=C3C=CSC3=N2)=C1)NC4=CC=C(C=C4)F
Biological Activity: hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
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hGGPPS-IN-2 | hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo. | |||||||||||||||||||||
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