2242470-43-3
2242470-43-3
Chemical Structure
DCZ0415
- CAS No.: 2242470-43-3
- Formula:C23H20N2O2
- Molecular Weight:356.42
IUPAC Name: 2-(4-(pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
InChIKey: LOXMLWHUIONWMI-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=C(CC3=CC=NC=C3)C=C2)C(C4C5C(C6)C6C(C=C5)C14)=O
Biological Activity: DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients[1].
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DCZ0415 | 99.81% | DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients. | ||||||||||||||||||||
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References
Keywords
