2244269-74-5
2244269-74-5
Chemical Structure
GPR84 antagonist 2
- CAS No.: 2244269-74-5
- Formula:C28H16Cl2NaO4PS2
- Molecular Weight:605.42
IUPAC Name: sodium bis(1-chlorodibenzo[b,f]thiepin-10-yl) phosphate
InChIKey: JFIDCMUEKCPJLL-UHFFFAOYSA-M
SMILES: O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)O[Na]
Biological Activity: GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GPR84 antagonist 2 | 99.06% | GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
