2. GPCR/G Protein
  3. GPR84
  4. GPR84 antagonist 2

GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis.

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GPR84 antagonist 2 Chemical Structure

GPR84 antagonist 2 Chemical Structure

CAS No. : 2244269-74-5

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Description

GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].

Molecular Weight

605.42

Formula

C28H16Cl2NaO4PS2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (206.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6517 mL 8.2587 mL 16.5175 mL
5 mM 0.3303 mL 1.6517 mL 3.3035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6517 mL 8.2587 mL 16.5175 mL 41.2936 mL
5 mM 0.3303 mL 1.6517 mL 3.3035 mL 8.2587 mL
10 mM 0.1652 mL 0.8259 mL 1.6517 mL 4.1294 mL
15 mM 0.1101 mL 0.5506 mL 1.1012 mL 2.7529 mL
20 mM 0.0826 mL 0.4129 mL 0.8259 mL 2.0647 mL
25 mM 0.0661 mL 0.3303 mL 0.6607 mL 1.6517 mL
30 mM 0.0551 mL 0.2753 mL 0.5506 mL 1.3765 mL
40 mM 0.0413 mL 0.2065 mL 0.4129 mL 1.0323 mL
50 mM 0.0330 mL 0.1652 mL 0.3303 mL 0.8259 mL
60 mM 0.0275 mL 0.1376 mL 0.2753 mL 0.6882 mL
80 mM 0.0206 mL 0.1032 mL 0.2065 mL 0.5162 mL
100 mM 0.0165 mL 0.0826 mL 0.1652 mL 0.4129 mL
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GPR84 antagonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR84 antagonist 22244269-74-5GPR84G protein coupled receptor 84oralselectivecalcium mobilizationchemotaxisneutrophilsulcerative colitisInhibitorinhibitorinhibit

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