2244568-06-5
2244568-06-5
Chemical Structure
Thalidomide-1-Me,4-OH
- CAS No.: 2244568-06-5
- Formula:C14H12N2O5
- Molecular Weight:288.26
IUPAC Name: methyl 4-(fluorocarbonyl)benzoate
InChIKey: DYFPLJSQQAPUSL-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3O)=O
Biological Activity: Thalidomide-1-Me,4-OH is a Thalidomide (HY-14658) analogue. Thalidomide-1-Me,4-OH contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thalidomide-1-Me,4-OH | 98.0% | Thalidomide-1-Me,4-OH is a Thalidomide (HY-14658) analogue. Thalidomide-1-Me,4-OH contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction. | ||||||||||||||||||||
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