Thalidomide-1-Me,4-OH
Based on 1 Customer Validation
Thalidomide-1-Me,4-OH is a Thalidomide (HY-14658) analogue. Thalidomide-1-Me,4-OH contains an extra methyl group on the glutarimide moiety of thalidomide, which is known to abrogate its ability to bind the E3 ligase CRBN. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2244568-06-5
- Formula: C14H12N2O5
- Molecular Weight:288.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 2244568-06-5
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Appearance Solid
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Molecular Weight 288.26
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Formula C14H12N2O5
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SMILES
O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (86.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4691 mL | 17.3455 mL | 34.6909 mL | 86.7273 mL |
| 5 mM | 0.6938 mL | 3.4691 mL | 6.9382 mL | 17.3455 mL | |
| 10 mM | 0.3469 mL | 1.7345 mL | 3.4691 mL | 8.6727 mL | |
| 15 mM | 0.2313 mL | 1.1564 mL | 2.3127 mL | 5.7818 mL | |
| 20 mM | 0.1735 mL | 0.8673 mL | 1.7345 mL | 4.3364 mL | |
| 25 mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 3.4691 mL | |
| 30 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8909 mL | |
| 40 mM | 0.0867 mL | 0.4336 mL | 0.8673 mL | 2.1682 mL | |
| 50 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7345 mL | |
| 60 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4455 mL | |
| 80 mM | 0.0434 mL | 0.2168 mL | 0.4336 mL | 1.0841 mL |
Thalidomide-1-Me,4-OH Related Classifications
HY-W441376 Related Classifications
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