2244702-64-3
2244702-64-3
Chemical Structure
TGase2-IN-1
- CAS No.: 2244702-64-3
- Formula:C23H25N3O3
- Molecular Weight:391.46
SMILES: O=C1C=C(C(C2=NC(C3=CC=C(OC4CCN(C(C)C)CC4)C=C3)=CC=C12)=O)N
Biological Activity: TGase2-IN-1 (Compound 22) is an orally active inhibitor for TGase2 with an IC50 of 1.12 μM. TGase2-IN-1 inhibits TGase2 in human retinal microvascular endothelial cells with an IC50 of 0.07 μM. TGase2-IN-1 exhibits 74.6% oral bioavailability. TGase2-IN-1 inhibits retinal vascular leakage in mouse Streptozotocin (HY-13753)-induced diabetic model[1].
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TGase2-IN-1 | TGase2-IN-1 (Compound 22) is an orally active inhibitor for TGase2 with an IC50 of 1.12 μM. TGase2-IN-1 inhibits TGase2 in human retinal microvascular endothelial cells with an IC50 of 0.07 μM. TGase2-IN-1 exhibits 74.6% oral bioavailability. TGase2-IN-1 inhibits retinal vascular leakage in mouse Streptozotocin (HY-13753)-induced diabetic model. | |||||||||||||||||||||
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