2245053-57-8
2245053-57-8
Chemical Structure
Etavopivat
Synonym(s): FT-4202
- CAS No.: 2245053-57-8
- Formula:C22H23N3O6S
- Molecular Weight:457.50
IUPAC Name: (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one
InChIKey: KZFFYEPYCVDOGE-LJQANCHMSA-N
SMILES: O=S(N1CC2=C(CN(C2)C([C@@H](C3=CC=CC=C3)CO)=O)C1)(C4=CN=C(OCCO5)C5=C4)=O
Biological Activity: Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Etavopivat | 99.91% | Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase (PKR) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies. | ||||||||||||||||||||
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References
- [1]. Shrestha A, et al. FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice. Blood Adv. 2021 May 11;5(9):2385-2390. [Content Brief]
- [2]. Schroeder P, et al. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 Mar;380(3):210-219. [Content Brief]
