2248068-54-2
Chemical Structure
Poloppin II
- CAS No.: 2248068-54-2
- Formula:C28H25ClF3N3O
- Molecular Weight:511.97
IUPAC Name: 4-(5-(4-chlorophenyl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)-N-(2-(dimethylamino)ethyl)benzamide
InChIKey: BBRZVOJNDJLHJP-UHFFFAOYSA-N
SMILES: O=C(NCCN(C)C)C1=CC=C(C=C1)C2=CC=C(C=3C=CC(Cl)=CC3)N2C=4C=CC=CC4C(F)(F)F
Biological Activity: Poloppin II is an orally active PBD inhibitor that blocks the binding of phosphopeptide substrates to PLK1/PLK2 PBD, with IC50 values of 41 µM and 105 µM for human PLK1/PLK2 PBD, respectively. Poloppin II binds to PLK4 PBD to inhibit PLK4-dependent mitotic functions. Poloppin II can be used in research on kras-mutant colorectal cancer[1].
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Poloppin II | Poloppin II is an orally active PBD inhibitor that blocks the binding of phosphopeptide substrates to PLK1/PLK2 PBD, with IC50 values of 41 µM and 105 µM for human PLK1/PLK2 PBD, respectively. Poloppin II binds to PLK4 PBD to inhibit PLK4-dependent mitotic functions. Poloppin II can be used in research on kras-mutant colorectal cancer. | |||||||||||||||||||||
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