2252448-93-2
2252448-93-2
Chemical Structure
Kv2.1-IN-1
- CAS No.: 2252448-93-2
- Formula:C22H29N3O3
- Molecular Weight:383.48
InChIKey: SVTYEIYBHHWMJJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC(NC(C(C)C)=O)=CC=C1OCC)NC(C2=CC=CC(NC)=C2)C
Biological Activity: Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC50 of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K+, Na+, and Ca2+ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H2O2. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke[1].
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Kv2.1-IN-1 | 98.64% | Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC50 of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K+, Na+, and Ca2+ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H2O2. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke. | ||||||||||||||||||||
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