225521-80-2
Chemical Structure
BMS-243117
- CAS 番号: 225521-80-2
- Formula:C20H21ClN4O2S
- Molecular Weight:416.92
IUPAC Name: 2-(3-(tert-butyl)ureido)-N-(2-chloro-6-methylphenyl)benzo[d]thiazole-6-carboxamide
InChIKey: FIVXJBFMVDAATB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(NC(NC(C)(C)C)=O)SC2=C1)NC3=C(C)C=CC=C3Cl
Biological Activity: BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck[1].
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BMS-243117 | BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck. | |||||||||||||||||||||
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Keywords
