225666-85-3
225666-85-3
Chemical Structure
K-832
- CAS No.: 225666-85-3
- Formula:C24H19ClN2OS
- Molecular Weight:418.94
IUPAC Name: 2-benzyl-5-(4-chlorophenyl)-6-(4-(methylthio)phenyl)pyridazin-3(2H)-one
InChIKey: HEUAVAATAFEENP-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(Cl)C=C2)C(C3=CC=C(SC)C=C3)=NN1CC4=CC=CC=C4
Biological Activity: K-832 is an orally active IL-1β secretion inhibitor. K-832 can be used in the research of rheumatoid arthritis[1][2].
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K-832 | K-832 is an orally active IL-1β secretion inhibitor. K-832 can be used in the research of rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Dumont F J. The interleukin-1 families of cytokines and receptors: therapeutic potential for immunomodulation and the treatment of inflammatory disorders. Expert Opinion on Therapeutic Patents, 2006, 16(7): 879-912.
- [2]. Halim S A, et al. Attempt to explore the binding mechanism of IL-1β inhibitors via molecular docking studies. Med. Chem, 2015, 5(10): 452-457.
Keywords
