2259301-27-2
Chemical Structure
Bexmarilimab
Synonym(s): FP-1305
- CAS No.: 2259301-27-2
- Formula:N/A
- Molecular Weight:(146.22 kDa)
IUPAC Name: 4-(aminomethyl)tetrahydro-2H-pyran-4-carbonitrile hydrochloride
SMILES: [Bexmarilimab]
Biological Activity: Bexmarilimab (FP-1305) is a potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab is capable of inducing a phenotypic M2 to M1 immune switch of tumor-associated macrophages. Bexmarilimab can promote antigen presentation and pro-inflammatory cytokine secretion. Bexmarilimab can induce B-cell and T-cell activation. Bexmarilimab can be used in researches of immunology and cancer, such as colorectal carcinoma[1][2].
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Bexmarilimab | 95.00% | Bexmarilimab (FP-1305) is a potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab is capable of inducing a phenotypic M2 to M1 immune switch of tumor-associated macrophages. Bexmarilimab can promote antigen presentation and pro-inflammatory cytokine secretion. Bexmarilimab can induce B-cell and T-cell activation. Bexmarilimab can be used in researches of immunology and cancer, such as colorectal carcinoma. | ||||||||||||||||||||
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- [1]. Hollmén M, et al. Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers. Mol Cancer Ther. 2022 Jul 5;21(7):1207-1218. [Content Brief]
- [2]. Elisa M. Vuorinen, et al. Bexmarilimab induces B-cell activation and autoantibody production. Cancer Res 1 April 2023; 83 (7_Supplement): 2269.
Keywords
