2260904-47-8
Chemical Structure
MMV688533
- CAS No.: 2260904-47-8
- Formula:C24H15F6N5O2
- Molecular Weight:519.40
IUPAC Name: tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,3a,4,7,7a-hexahydro-2H-isoindole-2-carboxylate
InChIKey: GGTONGQHYUQSBR-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C#CC2=CC=C(C(F)(F)F)C(C(NC3=NC=CC=C3)=O)=C2)=CC(C(F)(F)F)=C1)NC(N)=N
Biological Activity: MMV688533 is an antimalarial agent. MMV688533 interferes with intracellular trafficking, lipid utilization, and endocytosis pathways in Plasmodium falciparum. MMV688533 rapidly kills asexual blood-stage Plasmodium falciparum and Plasmodium vivax parasites in vitro and reduces parasitemia in a Plasmodium falciparum NSG mouse model. MMV688533 can be used for the research of malaria[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MMV688533 | 99.50% | MMV688533 is an antimalarial agent. MMV688533 interferes with intracellular trafficking, lipid utilization, and endocytosis pathways in Plasmodium falciparum. MMV688533 rapidly kills asexual blood-stage Plasmodium falciparum and Plasmodium vivax parasites in vitro and reduces parasitemia in a Plasmodium falciparum NSG mouse model. MMV688533 can be used for the research of malaria. | ||||||||||||||||||||
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- [1]. Murithi JM, et al. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Sci Transl Med. 2021 Jul 21;13(603):eabg6013. [Content Brief]
- [2]. Kavthe RD, et al. A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533. Chem Sci. 2023;14(23):6399-6407. Published 2023 May 26. [Content Brief]
Keywords
