22738-98-3
Chemical Structure
Ilicicolin F
Synonym(s): LL-Z 1272ζ
- CAS No.: 22738-98-3
- Formula:C25H31ClO6
- Molecular Weight:462.96
IUPAC Name: (1S,2S,3S,4R)-3-((1E,3E)-5-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3-methylpenta-1,3-dien-1-yl)-2,3,4-trimethyl-5-oxocyclohexyl acetate
InChIKey: ACSLMZYXJATICN-IRMIYARYSA-N
SMILES: O=CC1=C(C)C(Cl)=C(O)C(C/C=C(C)/C=C/[C@@]2(C)[C@H](C)[C@@H](OC(C)=O)CC([C@@H]2C)=O)=C1O
Biological Activity: Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo (IC50s=0.43 and 0.37 μM, respectively) but not the E. coli ubiquinol oxidase cytochrome bd (IC50=85 μM).2 Ilicicolin F is active against the fungi A. fumigatus and C. albicans (MICs=1.66-3.33 and 6.66-13.33 μg/mL, respectively). It is cytotoxic to HeLa cells with an EC50 value of 0.003 μg/mL.
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Ilicicolin F | Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo (IC50s=0.43 and 0.37 μM, respectively) but not the E. coli ubiquinol oxidase cytochrome bd (IC50=85 μM).2 Ilicicolin F is active against the fungi A. fumigatus and C. albicans (MICs=1.66-3.33 and 6.66-13.33 μg/mL, respectively). It is cytotoxic to HeLa cells with an EC50 value of 0.003 μg/mL. | |||||||||||||||||||||
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