22897-08-1
Chemical Structure
5-Methoxysterigmatocystin
- CAS No.: 22897-08-1
- Formula:C19H14O7
- Molecular Weight:354.31
IUPAC Name: (3aR,12cS)-8-hydroxy-6,11-dimethoxy-3a,12c-dihydro-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one
InChIKey: VVRUNWFPOWIBDY-WPCRTTGESA-N
SMILES: O=C1C2=C(OC3=C1C(O)=CC=C3OC)C4=C(O[C@]5([H])[C@@]4([H])C=CO5)C=C2OC
Biological Activity: 5-Methoxysterigmatocystin is a mycotoxin with cytotoxic and genotoxic properties. 5-Methoxysterigmatocystin exhibits cytotoxicity against cancer cells A549 and HepG2 (IC50 of 5.5 and 0.7 μM), and induces DNA damage. 5-Methoxysterigmatocystin is a photosensitizer, which utilizes the visible to generate singlet oxygen (1O2)[1][2].
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5-Methoxysterigmatocystin | 5-Methoxysterigmatocystin is a mycotoxin with cytotoxic and genotoxic properties. 5-Methoxysterigmatocystin exhibits cytotoxicity against cancer cells A549 and HepG2 (IC50 of 5.5 and 0.7 μM), and induces DNA damage. 5-Methoxysterigmatocystin is a photosensitizer, which utilizes the visible to generate singlet oxygen (1O2). | |||||||||||||||||||||
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- [1]. Dabelić S, et al., Sterigmatocystin, 5-Methoxysterigmatocistin, and Their Combinations Are Cytotoxic and Genotoxic to A549 and Hepg2 Cells and Provoke Phosphorylation of Chk2, but Not Fancd2 Checkpoint Proteins. Toxins (Basel). 2021 Jun 30;13(7):464. [Content Brief]
- [2]. Espinoza C, et al., Photosensitizer ability of 5-methoxysterigmatocystin isolated from aquatic fungus Acremonium persicinum[J]. Electronic Journal of Biotechnology, 2023, 62: 21-26.
Keywords
