229180-41-0
Chemical Structure
Contulakin G
- CAS No.: 229180-41-0
- Formula:C88H140N20O37
- Molecular Weight:2070.17
IUPAC Name: (4S,7S,16S,19S,22S,25S,28S,31S)-25-((R)-1-(((2S,3R,4R,5R,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-(((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)ethyl)-35-amino-19-(2-amino-2-oxoethyl)-2
InChIKey: UTQHLYJFMFKSGI-ZSSDLMQHSA-N
SMILES: CC(N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1O[C@H](C)[C@H](NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CO)NC(CNC(CNC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]2NC(CC2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CO)O)O[C@@H]5O[C@@H]([C@@H]([C@@H]([C@H]5O)O)O)CO)=O
Biological Activity: Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent[1][2].
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Contulakin G | Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent. | |||||||||||||||||||||
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References
- [1]. Lee HK, et al. A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties. Front Pharmacol. 2015 Feb 10;6:11. [Content Brief]
- [2]. Allen JW, et al. An assessment of the antinociceptive efficacy of intrathecal and epidural contulakin-G in rats and dogs. Anesth Analg. 2007 Jun;104(6):1505-13, table of contents. [Content Brief]
