2293951-00-3
Chemical Structure
Anti-inflammatory agent 35
- CAS No.: 2293951-00-3
- Formula:C27H29NO8
- Molecular Weight:495.52
IUPAC Name: 2-methoxy-4-((E)-3-oxo-3-(2-oxo-3-((E)-3,4,5-trimethoxybenzylidene)piperidin-1-yl)prop-1-en-1-yl)phenyl acetate
InChIKey: QLGWATTXCFBRGY-ZEQSIELKSA-N
SMILES: CC(OC1=CC=C(/C=C/C(N2C(/C(CCC2)=C/C3=CC(OC)=C(OC)C(OC)=C3)=O)=O)C=C1OC)=O
Biological Activity: Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo[1].
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Anti-inflammatory agent 35 | 99.77% | Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo. | ||||||||||||||||||||
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Keywords
