2300178-69-0
2300178-69-0
Chemical Structure
Etbicyphat-13C3
Synonym(s): Trimethylopropane phosphate-13C3
- CAS No.: 2300178-69-0
- Formula:C313C3H11O4P
- Molecular Weight:181.10
IUPAC Name: 4-ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide-3,4,5-13C3
InChIKey: BYEFHDZWRALTEN-JYLXJXPXSA-N
SMILES: CC[13C](CO1)([13CH2]O2)[13CH2]O[P]12=O
Biological Activity: Etbicyphat-13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors[1][2].
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Etbicyphat-13C3 | Etbicyphat-13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors. | |||||||||||||||||||||
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Etbicyphat | 98.0% | Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Rijal SO, et al. Dissociation constants for GABA(A) receptor antagonists determined with neuronal networks on microelectrode arrays. J Neurosci Methods. 2008 Aug 30;173(2):183-92. [Content Brief]
