2307429-54-3
2307429-54-3
Chemical Structure
SRI-35241
- CAS No.: 2307429-54-3
- Formula:C11H22N4O3
- Molecular Weight:258.32
InChIKey: XBCYIRCOIWJBTN-QMMMGPOBSA-N
SMILES: NC(C(C)(C)NC([C@@H](NC(C)=O)CCCN)=O)=O
Biological Activity: SRI-35241 is a thrombospondin TSP-1 inhibitor with a pIC50 of 8.12 nM against human targets. SRI-35241 inhibits the binding of TSP-1 to latent transforming growth factor-β-associated peptide (LAP) and blocks the activation of TGF-β. SRI-35241 shows a certain time-dependent property, with a plasma half-life of 1.8 h after intravenous administration. SRI-35241 can be used for the research of multiple myeloma and fibrotic diseases[1].
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SRI-35241 | SRI-35241 is a thrombospondin TSP-1 inhibitor with a pIC50 of 8.12 nM against human targets. SRI-35241 inhibits the binding of TSP-1 to latent transforming growth factor-β-associated peptide (LAP) and blocks the activation of TGF-β. SRI-35241 shows a certain time-dependent property, with a plasma half-life of 1.8 h after intravenous administration. SRI-35241 can be used for the research of multiple myeloma and fibrotic diseases. | |||||||||||||||||||||
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