2307699-34-7
Chemical Structure
Thi-DPPY
- CAS No.: 2307699-34-7
- Formula:C28H28ClN5O4S
- Molecular Weight:566.07
IUPAC Name: N-(3-((2-((3-chloro-4-(3-morpholinopropoxy)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
InChIKey: BZFLKUGURVDIAB-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(OC2=NC(NC3=CC(Cl)=C(C=C3)OCCCN4CCOCC4)=NC5=C2SC=C5)=CC=C1)=O
Biological Activity: Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1].
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Thi-DPPY | Thi-DPPY (compound 8e) is a potent and orally active JAK3 inhibitor with IC50 values of 62.4, 1.38 nM for BTK, JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF). | |||||||||||||||||||||
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Keywords
