231277-83-1
231277-83-1
Chemical Structure
ErbB-1/ErbB-2 tyrosine kinase-IN-1
- CAS No.: 231277-83-1
- Formula:C29H28N4O4S
- Molecular Weight:528.63
IUPAC Name: N-(4-(benzyloxy)phenyl)-6-(3-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine
InChIKey: ZBBOYUJFPDIEDF-UHFFFAOYSA-N
SMILES: O=S(=O)(C)CCNCC=1C=COC1C=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=CC5)C=C4)=C3C2
Biological Activity: ErbB-1/ErbB-2 tyrosine kinase-IN-1 is a dual ErbB-1/ErbB-2 tyrosine kinase inhibitor with IC50 values of 0.027 μM and 0.026 μM. ErbB-1/ErbB-2 tyrosine kinase-IN-1 targets the ATP binding region of ErbB-1 and ErbB-2 tyrosine kinases. ErbB-1/ErbB-2 tyrosine kinase-IN-1 inhibits cancer cells proliferation[1].
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ErbB-1/ErbB-2 tyrosine kinase-IN-1 | ErbB-1/ErbB-2 tyrosine kinase-IN-1 is a dual ErbB-1/ErbB-2 tyrosine kinase inhibitor with IC50 values of 0.027 μM and 0.026 μM. ErbB-1/ErbB-2 tyrosine kinase-IN-1 targets the ATP binding region of ErbB-1 and ErbB-2 tyrosine kinases. ErbB-1/ErbB-2 tyrosine kinase-IN-1 inhibits cancer cells proliferation. | |||||||||||||||||||||
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