ErbB-1/ErbB-2 tyrosine kinase-IN-1
ErbB-1/ErbB-2 tyrosine kinase-IN-1 is a dual ErbB-1/ErbB-2 tyrosine kinase inhibitor with IC50 values of 0.027 μM and 0.026 μM. ErbB-1/ErbB-2 tyrosine kinase-IN-1 targets the ATP binding region of ErbB-1 and ErbB-2 tyrosine kinases. ErbB-1/ErbB-2 tyrosine kinase-IN-1 inhibits cancer cells proliferation.
For research use only. We do not sell to patients.
- CAS No.: 231277-83-1
- Formula: C29H28N4O4S
- Molecular Weight:528.63
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
Description
In Vitro
ErbB-1/ErbB-2 tyrosine kinase-IN-1 (Compound 2) potently inhibits ErbB-1 and ErbB-2 tyrosine kinases with IC50 values of 0.027 μM and 0.026 μM, respectively[1].
ErbB-1/ErbB-2 tyrosine kinase-IN-1 (72 h) inhibits proliferation of HN5, BT474, and N87 tumor cells with IC50 values of 0.65 μM, 0.28 μM, and 0.87 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 231277-83-1
-
Molecular Weight 528.63
-
Formula C29H28N4O4S
-
SMILES
O=S(=O)(C)CCNCC=1C=COC1C=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=CC5)C=C4)=C3C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ErbB-1/ErbB-2 tyrosine kinase-IN-1 Related Classifications
HY-123726 Related Classifications
Powered by Bioz