2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. ErbB-1/ErbB-2 tyrosine kinase-IN-1

ErbB-1/ErbB-2 tyrosine kinase-IN-1 is a dual ErbB-1/ErbB-2 tyrosine kinase inhibitor with IC50 values of 0.027 μM and 0.026 μM. ErbB-1/ErbB-2 tyrosine kinase-IN-1 targets the ATP binding region of ErbB-1 and ErbB-2 tyrosine kinases. ErbB-1/ErbB-2 tyrosine kinase-IN-1 inhibits cancer cells proliferation.

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ErbB-1/ErbB-2 tyrosine kinase-IN-1

ErbB-1/ErbB-2 tyrosine kinase-IN-1 Chemical Structure

CAS No. : 231277-83-1

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ErbB-1/ErbB-2 tyrosine kinase-IN-1 Related Antibodies

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Description

ErbB-1/ErbB-2 tyrosine kinase-IN-1 is a dual ErbB-1/ErbB-2 tyrosine kinase inhibitor with IC50 values of 0.027 μM and 0.026 μM. ErbB-1/ErbB-2 tyrosine kinase-IN-1 targets the ATP binding region of ErbB-1 and ErbB-2 tyrosine kinases. ErbB-1/ErbB-2 tyrosine kinase-IN-1 inhibits cancer cells proliferation[1].

In Vitro

ErbB-1/ErbB-2 tyrosine kinase-IN-1 (Compound 2) potently inhibits ErbB-1 and ErbB-2 tyrosine kinases with IC50 values of 0.027 μM and 0.026 μM, respectively[1].
ErbB-1/ErbB-2 tyrosine kinase-IN-1 (72 h) inhibits proliferation of HN5, BT474, and N87 tumor cells with IC50 values of 0.65 μM, 0.28 μM, and 0.87 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ErbB-1/ErbB-2 tyrosine kinase-IN-1 Related Antibodies
Molecular Weight

528.63

Formula

C29H28N4O4S
CAS No.
SMILES

O=S(=O)(C)CCNCC=1C=COC1C=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=CC5)C=C4)=C3C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ErbB-1/ErbB-2 tyrosine kinase-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ErbB-1/ErbB-2 tyrosine kinase-IN-1231277-83-1EGFREpidermal growth factor receptorErbB-1HER1N87 tumor cellsHN5 tumor cellsATP binding regionErbB-1 tyrosine kinaseErbB-2 tyrosine kinasegastric cancerBT474 tumor cellshead and neck cancerbreast cancerInhibitorinhibitorinhibit

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