23256-40-8
23256-40-8
Chemical Structure
Guanoxabenz hydrochloride
Synonym(s): Hydroxyguanabenz hydrochloride
- CAS No.: 23256-40-8
- Formula:C8H9Cl3N4O
- Molecular Weight:283.54
IUPAC Name: (E)-2-(2,6-dichlorobenzylidene)-N-hydroxyhydrazine-1-carboximidamide hydrochloride
InChIKey: PQPZROSFRCBPIM-AQCBZIOHSA-N
SMILES: ClC1=C(/C=N/NC(NO)=N)C(Cl)=CC=C1.[H]Cl
Biological Activity: Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3].
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Guanoxabenz hydrochloride | 99.72% | Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor. | ||||||||||||||||||||
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References
- [1]. Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmac [Content Brief]
- [2]. Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cyto [Content Brief]
- [3]. Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83(4):158-63. [Content Brief]
Keywords
