23273-91-8
Chemical Structure
Glycylglycine hydrochloride hydrate
Synonym(s): Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)
- CAS No.: 23273-91-8
- Formula:C4H11ClN2O4
- Molecular Weight:186.59
IUPAC Name: glycylglycine hydrochloride hydrate
InChIKey: KHYIJCMSLMRPDS-UHFFFAOYSA-N
SMILES: O=C(CNC(CN)=O)O.Cl.O
Biological Activity: Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis)[1][2].
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Glycylglycine hydrochloride hydrate | Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis). | |||||||||||||||||||||
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- [1]. Xu B, et al. Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells. Mol Med Rep. 2019 Oct;20(4):3802-3810. [Content Brief]
- [2]. Zhao C, et al. Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects. J Pharm Biomed Anal. 2015 Nov 10;115:48-54. [Content Brief]
Keywords
