2358714-71-1
2358714-71-1
Chemical Structure
SRI-37264
- CAS No.: 2358714-71-1
- Formula:C17H14ClN3O3S
- Molecular Weight:375.83
InChIKey: MZBFJSQDRFBYKT-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CN=C2SN1C3=CC=C(C(C(N4CCOCC4)=O)=C3)Cl
Biological Activity: SRI-37264 is a HIV-1 Nef inhibitor with a Kd value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection[1].
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SRI-37264 | SRI-37264 is a HIV-1 Nef inhibitor with a Kd value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection. | |||||||||||||||||||||
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