2364639-42-7
Chemical Structure
S-Geranylgeranyl-L-glutathione
- CAS No.: 2364639-42-7
- Formula:C30H49N3O6S
- Molecular Weight:579.79
IUPAC Name: N5-((R)-1-((carboxymethyl)amino)-1-oxo-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propan-2-yl)-L-glutamine
InChIKey: BAJIBEVLRWVBAZ-DPRMOSMCSA-N
SMILES: OC([C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O)=O
Biological Activity: S-Geranylgeranyl-L-glutathione is a P2RY8 inhibitor and intercellular signaling molecule that exists endogenously in human bone marrow interstitial fluid. S-Geranylgeranyl-L-glutathione promotes the internalization of P2RY8 and antagonizes chemokine-induced activation of pAkt. S-Geranylgeranyl-L-glutathione negatively regulates the migration of B cells and T cells to the bone marrow, inhibits chemokine-mediated migration of germinal center B cells and follicular helper T cells, participates in lymphocyte guidance regulation, and modulates the germinal center response process. S-Geranylgeranyl-L-glutathione can be used in research related to diffuse large B-cell lymphoma and Burkitt lymphoma[1][2].
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S-Geranylgeranyl-L-glutathione | S-Geranylgeranyl-L-glutathione is a P2RY8 inhibitor and intercellular signaling molecule that exists endogenously in human bone marrow interstitial fluid. S-Geranylgeranyl-L-glutathione promotes the internalization of P2RY8 and antagonizes chemokine-induced activation of pAkt. S-Geranylgeranyl-L-glutathione negatively regulates the migration of B cells and T cells to the bone marrow, inhibits chemokine-mediated migration of germinal center B cells and follicular helper T cells, participates in lymphocyte guidance regulation, and modulates the germinal center response process. S-Geranylgeranyl-L-glutathione can be used in research related to diffuse large B-cell lymphoma and Burkitt lymphoma. | |||||||||||||||||||||
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- [1]. Gallman AE, et al. Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of -geranylgeranyl-l-glutathione. Science immunology. 2021 Jun 04;6(60):eabg1101. [Content Brief]
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[2]. Lu, E., et al. (2019). S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Nature, 567(7747), 244-248.
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