2365532-64-3
Chemical Structure
Copper Fluor-4
Synonym(s): CF4
- CAS No.: 2365532-64-3
- Formula:C38H47F3N2O2S4
- Molecular Weight:749.05
IUPAC Name: N-methylethan-1,1-d2-1-amine
InChIKey: IWSHBHVMVNQFGF-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(C3=C(C(F)(F)F)C=C(CN(CCSCCSCC)CCSCCSCC)C=C3)C4=C(C=C(N5CCCCC5)C=C4)OC2=C1
Biological Activity: Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10−13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Copper Fluor-4 | 95.11% | Copper Fluor-4 (CF4) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10−13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission). | ||||||||||||||||||||
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Copper Fluor-4 (solution) | Copper Fluor-4 (solution) (CF4 (solution)) is a Cu+-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 solution has high copper selectivity with a Kd value of 2.9×10?13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 solution is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission). Solvent and concentration: DMSO: 5 mM |
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References
- [1]. Xiao T, et al. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 2018 Jul;14(7):655-663. [Content Brief]
- [2]. Weishaupt AK, et al. Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans. Front Mol Biosci. 2024 Feb 8;11:1354627. [Content Brief]
- [3]. Chakraborty K, et al. Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia. Metallomics. 2022 Apr 1;14(4):mfac005. [Content Brief]
