2374772-46-8
Chemical Structure
J-1063
- CAS No.: 2374772-46-8
- Formula:C24H19N5OS
- Molecular Weight:425.51
IUPAC Name: 2-(3-(6-methylpyridin-2-yl)-4-(thieno[3,2-c]pyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide
InChIKey: YVABZJGVIULAAE-UHFFFAOYSA-N
SMILES: CC1=NC(C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(NC5=CC=CC=C5)=O)=CC=C1
Biological Activity: J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis[1].
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J-1063 | J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 µM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis. | |||||||||||||||||||||
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Keywords
