2376687-49-7
Chemical Structure
UCK2 Inhibitor-3
- CAS. Nr.: 2376687-49-7
- Formula:C19H13BrFN5O2S
- Molecular Weight:474.31
IUPAC Name: 2-oxo-2-(phenyl-d5)acetic acid, sodium salt
InChIKey: NIKMWQYDUCMNGX-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Br)C=C1)CSC(N=C2C3=CNN2C4=CC=C(F)C=C4)=NC3=O
Biological Activity: UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 μM and 16 μM[1].
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UCK2 Inhibitor-3 | 98.65% | UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 μM and 16 μM. | ||||||||||||||||||||
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Keywords
