2378626-29-8
Chemical Structure
TED-347
- CAS No.: 2378626-29-8
- Formula:C15H11ClF3NO
- Molecular Weight:313.70
IUPAC Name: 2-chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one
InChIKey: JPVDFGYNLUBCSD-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl
Biological Activity: TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TED-347 | 99.13% | TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity. | ||||||||||||||||||||
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Keywords
