2390002-31-8
Chemical Structure
HMBI
- CAS No.: 2390002-31-8
- Formula:C18H18INO3S
- Molecular Weight:455.31
InChIKey: TZZTVYZZQDOYJW-UHFFFAOYSA-N
SMILES: C[N+]1=C(/C=C/C2=CC(OC)=C(O)C(OC)=C2)SC3=CC=CC=C31.[I-]
Biological Activity: HMBI is a fluorescent probe that enables dual-color visualization of both the nucleus and mitochondria and monitors apoptosis. HMBI emits green fluorescence in the nucleus with Ex/Em=405/510-560 nm, and red fluorescence in mitochondria with Ex/Em=543/560-660 nm. The localization and emission properties of HMBI depend on subcellular pH and mitochondrial membrane potential. HMBI can serve as a feed additive for in vitro rumen fermentation; it is partially degraded, absorbed or converted into HMB by microorganisms in the system, so as to support microbial protein synthesis, alter the concentration of rumen metabolites and adjust the composition of bacterial communities[1][2].
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HMBI | HMBI is a fluorescent probe that enables dual-color visualization of both the nucleus and mitochondria and monitors apoptosis. HMBI emits green fluorescence in the nucleus with Ex/Em=405/510-560 nm, and red fluorescence in mitochondria with Ex/Em=543/560-660 nm. The localization and emission properties of HMBI depend on subcellular pH and mitochondrial membrane potential. HMBI can serve as a feed additive for in vitro rumen fermentation; it is partially degraded, absorbed or converted into HMB by microorganisms in the system, so as to support microbial protein synthesis, alter the concentration of rumen metabolites and adjust the composition of bacterial communities. | |||||||||||||||||||||
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References
- [1]. Yang R, et al. A Single Fluorescent pH Probe for Simultaneous Two-Color Visualization of Nuclei and Mitochondria and Monitoring Cell Apoptosis. ACS sensors. 2021 Apr 23;6(4):1552-1559.
- [2]. Li S, et al. Effect of Methionine Hydroxy Analog on Hu Sheep Digestibility, Rumen Fermentation, and Rumen Microbial Community In Vitro. Metabolites. 2023 Jan 23;13(2):169.
