2408836-40-6
Chemical Structure
Anti-inflammatory agent 21
- No. CAS: 2408836-40-6
- Formula:C24H21FO6
- Molecular Weight:424.42
IUPAC Name: 3-((4-((4-fluorobenzyl)oxy)phenyl)(hydroxy)methyl)-5,7-dimethoxyisobenzofuran-1(3H)-one
InChIKey: YGDONXMKUYARJW-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C(OC)=C1)C(OC2C(C3=CC=C(C=C3)OCC4=CC=C(C=C4)F)O)=O
Biological Activity: Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].
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Anti-inflammatory agent 21 | Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model. | |||||||||||||||||||||
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