2410402-88-7
2410402-88-7
Chemical Structure
CDK2-IN-12
- No. CAS: 2410402-88-7
- Formula:C20H17N9O2S
- Molecular Weight:447.47
IUPAC Name: (E)-4-((2,7-diamino-6-cyano-5-(p-tolyl)pyrazolo[1,5-a]pyrimidin-3-yl)diazenyl)benzenesulfonamide
InChIKey: XIEZNUNKXXLJEK-CYYJNZCTSA-N
SMILES: O=S(C1=CC=C(/N=N/C2=C3N=C(C4=CC=C(C)C=C4)C(C#N)=C(N)N3N=C2N)C=C1)(N)=O
Biological Activity: CDK2-IN-12 (compound 10b) is a potent CDK2 inhibitor, with an IC50 of 11.6 μM. CDK2-IN-12 inhibits hCA (carbonic anhydrase) isoforms I, II, IX and XII, with KI values of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity[1].
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CDK2-IN-12 | CDK2-IN-12 (compound 10b) is a potent CDK2 inhibitor, with an IC50 of 11.6 μM. CDK2-IN-12 inhibits hCA (carbonic anhydrase) isoforms I, II, IX and XII, with KI values of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity. | |||||||||||||||||||||
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