2410557-01-4
Chemical Structure
iRucaparib-TP3
- CAS No.: 2410557-01-4
- Formula:C46H52FN9O8
- Molecular Weight:877.96
IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(2-(2-(4-(4-((4-(8-fluoro-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione
InChIKey: WOCUITLZAXIDDD-UHFFFAOYSA-N
SMILES: O=C1NCCC2=C(C3=CC=C(CN(C)CCCCC4=CN(CCOCCOCCOCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)N=N4)C=C3)NC8=CC(F)=CC1=C82
Biological Activity: iRucaparib-TP3 is a non-trapping PARP1 PROTAC degrader with concurrent PARP1 catalytic inhibitory activity. iRucaparib-TP3 induces PARP1 ubiquitination and subsequent proteasomal degradation. iRucaparib-TP3 can be used for the research of cervical adenocarcinoma[1].
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iRucaparib-TP3 | iRucaparib-TP3 is a non-trapping PARP1 PROTAC degrader with concurrent PARP1 catalytic inhibitory activity. iRucaparib-TP3 induces PARP1 ubiquitination and subsequent proteasomal degradation. iRucaparib-TP3 can be used for the research of cervical adenocarcinoma. | |||||||||||||||||||||
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