2411321-35-0

SHP2-IN-31 Chemical Structure
2411321-35-0

Chemical Structure

SHP2-IN-31

  • CAS No.: 2411321-35-0
  • Formula:C21H26Cl2N4O2
  • Molecular Weight:437.36

InChIKey: ABKATOFAZUIEJX-SCLBCKFNSA-N

SMILES: N[C@H]1C2(CO[C@H]1C)CCN(C3=C(C(N(C4=C(C(Cl)=CC=C4)Cl)C(C)=N3)=O)C)CC2

Biological Activity: SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models[1].

Cat. No. Product Name Purity Description Pricing
HY-164427 		SHP2-IN-31 SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models.
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