2412155-75-8
2412155-75-8
Chemical Structure
AST5902 mesylate
- CAS No.: 2412155-75-8
- Formula:C28H33F3N8O5S
- Molecular Weight:650.67
InChIKey: NQBRKLBKHDKWJB-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O.O=S(O)(C)=O
Biological Activity: AST5902 mesylate is the active metabolite of Furmonertinib (HY-112870) with antitumor activity, and acts as a EGFR inhibitor. AST5902 mesylate inhibits CYP3A4 mRNA transcription at low concentrations and induces CYP3A4 mRNA expression at high concentrations. AST5902 mesylate can be used in research related to non-small cell lung cancer[1][2].
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AST5902 mesylate | AST5902 mesylate is the active metabolite of Furmonertinib (HY-112870) with antitumor activity, and acts as a EGFR inhibitor. AST5902 mesylate inhibits CYP3A4 mRNA transcription at low concentrations and induces CYP3A4 mRNA expression at high concentrations. AST5902 mesylate can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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References
- [1]. Zou HX, et al. Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model. Acta pharmacologica Sinica. 2022 Jul;43(7):1865-1874.
- [2]. Liu XY, et al. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta pharmacologica Sinica. 2020 Oct;41(10):1366-1376. [Content Brief]
