2413100-40-8
2413100-40-8
Chemical Structure
PD-1-IN-25
- CAS No.: 2413100-40-8
- Formula:C37H35ClF2N2O9
- Molecular Weight:725.13
InChIKey: XWDCDNGWIWXWIW-SGINOMJUSA-N
SMILES: CC1=C(C=CC=C1C(F)(F)OC2=CC(OCC3=CC(C#N)=CC=C3)=C(C=C2Cl)CN[C@H]4[C@H]([C@@H]([C@H](OC4O)CO)O)O)C5=CC=C(OCCO6)C6=C5
Biological Activity: PD-1-IN-25 (compound 43) is a potent PD-1/PD-L1 interaction inhibitor with an IC50 value of 10.2 nM in the HTRF assay. PD-1-IN-25 can promote CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. PD-1-IN-25 delays the tumor growth[1].
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PD-1-IN-25 | PD-1-IN-25 (compound 43) is a potent PD-1/PD-L1 interaction inhibitor with an IC50 value of 10.2 nM in the HTRF assay. PD-1-IN-25 can promote CD8+ T cell activation through inhibiting PD-1/PD-L1 cellular signaling. PD-1-IN-25 delays the tumor growth. | |||||||||||||||||||||
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References
Keywords
