2413974-69-1
2413974-69-1
Chemical Structure
Mt KARI-IN-5
- CAS No.: 2413974-69-1
- Formula:C14H10N4O5S3
- Molecular Weight:410.45
IUPAC Name: 4-acetyl-N-(5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide
InChIKey: WFMFLZBQKIAQEH-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C=C1)S(=O)(NC2=NN=C(S2)C3=CC=C(S3)[N+]([O-])=O)=O)=O
Biological Activity: Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]
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Mt KARI-IN-5 | Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL) | |||||||||||||||||||||
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