2414921-48-3
Chemical Structure
PDE5/HDAC-IN-1
- CAS No.: 2414921-48-3
- Formula:C27H29BrN4O4
- Molecular Weight:553.45
IUPAC Name: 7-((6R,12aR)-6-(4-bromophenyl)-1,4-dioxo-3,4,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2(1H)-yl)-N-hydroxyheptanamide
InChIKey: KNOXAVJMUDFKCL-ATIYNZHBSA-N
SMILES: O=C1N2[C@@](C3=CC=C(C=C3)Br)([H])C4=C(C[C@]2([H])C(N(C1)CCCCCCC(NO)=O)=O)C5=CC=CC=C5N4
Biological Activity: PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities[1].
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PDE5/HDAC-IN-1 | PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities. | |||||||||||||||||||||
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Keywords
