PDE5/HDAC-IN-1
PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities.
For research use only. We do not sell to patients.
- CAS No.: 2414921-48-3
- Formula: C27H29BrN4O4
- Molecular Weight:553.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE5 46.3 nM (IC50) |
HDAC6 0.11 μM (IC50) |
HDAC8 0.12 μM (IC50) |
HDAC1 2.45 μM (IC50) |
PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC50 values of 12.35, 7.19 and 11.79 µM against HT-29, HCT-116 and SW-620 cells, respectively[1].
PDE5/HDAC-IN-1 shows cytotoxic activity with IC50 values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2414921-48-3
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Molecular Weight 553.45
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Formula C27H29BrN4O4
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SMILES
O=C1N2[C@@](C3=CC=C(C=C3)Br)([H])C4=C(C[C@]2([H])C(N(C1)CCCCCCC(NO)=O)=O)C5=CC=CC=C5N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE5/HDAC-IN-1 Related Classifications
HY-147991 Related Classifications
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