PDE5/HDAC-IN-1
PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities.
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- CAS. Nr.: 2414921-48-3
- Formel: C27H29BrN4O4
- Molecular Weight:553.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
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PDE5 46.3 nM (IC50) |
HDAC6 0.11 μM (IC50) |
HDAC8 0.12 μM (IC50) |
HDAC1 2.45 μM (IC50) |
In Vitro
PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC50 values of 12.35, 7.19 and 11.79 µM against HT-29, HCT-116 and SW-620 cells, respectively[1].
PDE5/HDAC-IN-1 shows cytotoxic activity with IC50 values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2414921-48-3
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Molecular Weight 553.45
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Formel C27H29BrN4O4
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SMILES
O=C1N2[C@@](C3=CC=C(C=C3)Br)([H])C4=C(C[C@]2([H])C(N(C1)CCCCCCC(NO)=O)=O)C5=CC=CC=C5N4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PDE5/HDAC-IN-1 Related Classifications
HY-147991 Related Classifications
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